Reconstructive Transplant Research
Released: May 2, 2019
Defense Health Program
Department of Defense Reconstructive Transplant Research Program
Funding Opportunities for Fiscal Year 2019 (FY19)
The FY19 Defense Appropriation provides $12 million (M) to the Department of Defense Reconstructive Transplant Research Program (RTRP) to support research projects that specifically address needs in the field of vascularized composite allotransplantation (VCA). As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Materiel Command (USAMRMC).
The RTRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. FY19 RTRP Program Announcements and General Application Instructions for the following award mechanisms are anticipated to be posted on the Grants.gov website in May 2019. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the government.
Focus Areas: To meet the intent of the FY19 RTRP Idea Discovery Award and Investigator-Initiated Research Award mechanisms, applicants must address at least one of the FY19 RTRP Focus Areas listed below:
- Reduce the risks of VCA-associated immunosuppression
- Define the unique mechanisms of VCA immunogenicity
- Develop novel approaches for improving VCA immune tolerance
- Identify unique immunosuppression requirements for VCA compared to other solid organ transplants
- Develop reliable non-invasive methods or tools for monitoring VCA graft rejection
- Develop reliable non-invasive biomarkers for monitoring chronic VCA graft rejection in a large animal model
- Identify and/or validate new peripheral biomarkers for acute and chronic rejection
- Develop assays or devices for clinical graft monitoring utilizing validated biomarkers
- Advance existing or develop innovative ex vivo tissue preservation strategies to extend the timeline between procurement and transplantation
- Develop novel approaches and models for perfused, hypothermic, high subzero and low subzero, or static preservation strategies
- Determine the extent to which VCA tissue preservation technology impacts VCA immunogenicity
|Award Mechanism||Eligibility||Key Mechanism Elements||Funding|
|Idea Discovery Award||Investigators at or above the level of postdoctoral fellow (or equivalent).||
|Investigator-Initiated Research Award||Independent investigators at all academic levels (or equivalent).||
Multiple PI Option:
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRMC extramural Funding Opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the RTRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
Point of Contact:
CDMRP Public Affairs
Last updated Wednesday, May 1, 2019