DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Vision - A time when the causative links between Traumatic Brain Injury and epilepsy are understood and Post-Traumatic Epilepsy is both preventable and treatable

Epilepsy Program Cover Image
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Epilepsy Research Program Cover Image
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ERP Post-Traumatic Epilepsy Brief
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The ERP was initiated in 2015 to develop an understanding of the magnitude of post-traumatic epilepsy (PTE) within the military and to expand research into the basic mechanisms by which traumatic brain injury (TBI) produces epilepsy. To this end, and to satisfy the ERP's Mission and Vision, the ERP has identified the following research Focus Areas for FY19:

  • Innovative Research: Tools intended to better inform or improve upon how PTE research can be performed:
    • Hardware and/or software platforms that will improve seizure detection, characterization, or diagnosis
    • Bioinformatics strategies, to include machine learning, that will improve access, annotation, curation and visualization of large and novel datasets from single or multiple sources
    • Development of new models or better characterization of existing etiologically relevant models for PTE
    • Improved characterization of the circuits involved in PTE

  • Markers and Mechanisms: Identifying markers or mechanisms via preclinical models that address PTE, which may include the following:
    • Biomarkers
    • Therapeutic targets for epilepsy prevention
    • Early detection
    • Diagnosis
    • Prognosis
    • Comorbidity
    • Mortality
    • Risk stratification

  • Epidemiology: Epidemiological characterization of PTE following TBI, which may include the following:
    • Risk factors such as demographics, genetics, anatomy, pathology, or type of injury
    • Differentiation of PTE and psychogenic non-epileptic seizures (PNES)
    • Outcomes including latency to epilepsy, comorbidities, and mortality
    • Pre-existing conditions including psychological and psychiatric risk factors
    • Treatment and healthcare outcomes research

  • Longitudinal Studies: Studies of the evolution of PTE, which may include the following:
    • Seizure frequency and severity
    • Demographics, genetics, anatomy, pathology, or type of injury
    • Comorbidities (e.g., depression, functional deficits, sleep disorders, major illness)
    • Latency between type of injury and PTE
    • Mortality
    • Treatment and healthcare outcomes research
    • Quality of life of individuals with PTE and their caregivers


Congressional Appropriations

Congressional Appropriations

  • $30 million
    FY15-18
  • $7.5 million
    FY19

...

Funding
Summary


Related Videos

Dr. Karen Parko

Department of Veterans Affairs, Epilepsy Centers of Excellence
Resolving the Connection Between TBIs and Epilepsy

Jay Hennessy

Epilepsy Foundation of Florida
A Consumer’s Perspective: Two Minutes Could Change Your Life

news_icon News & Highlights

Vision

A time when the causative links between Traumatic Brain Injury and epilepsy are understood and Post-Traumatic Epilepsy is both preventable and treatable

Mission

To understand post-traumatic epilepsy and associated comorbidities to improve quality of life, especially in Service members, Veterans, and caregivers

Last updated Friday, September 13, 2019